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PRP (Platelet-Rich Plasma)
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Platelet-Rich Fibrin (PRF)
Platelet-Rich Fibrin (PRF) is an advanced, fully autologous (derived from the patient’s own body) blood concentrate used in regenerative aesthetics. Often considered the second generation of Platelet-Rich Plasma (PRP), PRF harnesses the body’s natural healing capabilities to achieve sustained tissue rejuvenation and improved skin quality.
Mechanism: The Fibrin Scaffold
The key to PRF’s efficacy lies in its preparation:
Preparation: A small sample of the patient’s blood is drawn and spun in a centrifuge at a lower speed than required for PRP.
No Additives: Crucially, PRF is processed without anticoagulants (chemicals that prevent blood clotting). This allows the blood to naturally clot.
Formation of the Fibrin Matrix: The final product is a dense, three-dimensional fibrin matrix rich in a high concentration of platelets, growth factors, white blood cells (leukocytes), and stem cells. This matrix acts as a biological scaffold, trapping the regenerative components.
Sustained Release: Once injected, the fibrin matrix slowly breaks down over an extended period (up to a week or more). This process allows for a gradual and sustained release of growth factors, offering a longer-lasting regenerative effect compared to the rapid, short-term release seen with older concentrates.
Aesthetic Benefits
PRF provides a natural boost to skin health, delivering results that are gradual and long-lasting:
Intense Collagen Stimulation: The prolonged release of growth factors powerfully stimulates fibroblasts to produce new collagen and elastin, leading to a visible reduction in fine lines and wrinkles.
Volumization and Firming: PRF helps restore lost volume in delicate areas, such as under-eye hollows and cheeks, providing a subtle, natural lifting and plumping effect. It is an excellent non-synthetic option for under-eye rejuvenation.
Tissue Regeneration: It significantly improves skin texture and tone, aiding in the remodeling of scars (especially acne scars), reducing inflammation, and enhancing the overall vitality and radiance of the skin.
Enhanced Healing: The presence of white blood cells accelerates the healing process, making PRF an ideal complementary treatment when combined with other procedures like microneedling or laser resurfacing.
Natural and Safe: Since PRF is 100% autologous (derived from the patient’s own body) and contains no artificial additives, the risk of allergic reactions or adverse effects is extremely minimal.